The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist

B-cell lymphoma-2 (Bcl-2) proteins mediate intrinsic-, or mitochondrial-, initiated apoptosis. We have investigated the structure and function of the least characterized Bcl-2 family member, Bcl-B, solving the crystal structure of a Bcl-B:Bim complex to 1.9 Å resolution. Bcl-B is distinguished from...

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Bibliografske podrobnosti
Main Authors: Rautureau, G J P, Yabal, M, Yang, H, Huang, D C S, Kvansakul, M, Hinds, M G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542614/
https://ncbi.nlm.nih.gov/pubmed/23235460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.178
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