BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins (BID, BIM, etc.) directly engage and allosterically activate effector proteins BAX/BAK. Here, through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins, we demonstrate th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Res
Prif Awduron: Huang, Kai, O’Neill, Katelyn L., Li, Jian, Zhou, Wei, Han, Na, Pang, Xiaming, Wu, Wei, Struble, Lucas, Borgstahl, Gloria, Liu, Zhaorui, Zhang, Liqiang, Luo, Xu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888900/
https://ncbi.nlm.nih.gov/pubmed/31551537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0231-y
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