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BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins (BID, BIM, etc.) directly engage and allosterically activate effector proteins BAX/BAK. Here, through reconstitution of cells lacking all eight pro-apoptotic BH3-only proteins, we demonstrate th...
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| 出版年: | Cell Res |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6888900/ https://ncbi.nlm.nih.gov/pubmed/31551537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0231-y |
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