Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

Anti-apoptotic Bcl-2 family proteins, which inhibit the mitochondrial pathway of apoptosis, are involved in the survival of various hematopoietic lineages and are often dysregulated in hematopoietic malignancies. However, their involvement in the megakaryocytic lineage is not well understood. In the...

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Bibliographische Detailangaben
Hauptverfasser: Kodama, T, Hikita, H, Kawaguchi, T, Shigekawa, M, Shimizu, S, Hayashi, Y, Li, W, Miyagi, T, Hosui, A, Tatsumi, T, Kanto, T, Hiramatsu, N, Kiyomizu, K, Tadokoro, S, Tomiyama, Y, Hayashi, N, Takehara, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469054/
https://ncbi.nlm.nih.gov/pubmed/22790873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.88
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