BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS

A pivotal step in the mitochondrial pathway of apoptosis is activation of Bak and Bax, although the molecular mechanism remains controversial. To examine whether mitochondrial apoptosis can be induced by just a lack of antiapoptotic Bcl-2-like proteins or requires direct activators of the BH3-only p...

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Detalhes bibliográficos
Main Authors: Kodama, Takahiro, Takehara, Tetsuo, Hikita, Hayato, Shimizu, Satoshi, Shigekawa, Minoru, Li, Wei, Miyagi, Takuya, Hosui, Atsushi, Tatsumi, Tomohide, Ishida, Hisashi, Kanto, Tatsuya, Hiramatsu, Naoki, Yin, Xiao-Ming, Hayashi, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077591/
https://ncbi.nlm.nih.gov/pubmed/21367852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195370
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