Bax dimerizes via a symmetric BH3:groove interface during apoptosis

During apoptotic cell death, Bax and Bak change conformation and homo-oligomerize to permeabilize mitochondria. We recently reported that Bak homodimerizes via an interaction between the BH3 domain and hydrophobic surface groove, that this BH3:groove interaction is symmetric, and that symmetric dime...

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Detaylı Bibliyografya
Asıl Yazarlar: Dewson, G, Ma, S, Frederick, P, Hockings, C, Tan, I, Kratina, T, Kluck, R M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307980/
https://ncbi.nlm.nih.gov/pubmed/22015607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.138
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