Bcl-2 and Bax Interact via the BH1–3 Groove-BH3 Motif Interface and a Novel Interface Involving the BH4 Motif

The interaction of Bcl-2 family proteins at the mitochondrial outer membrane controls membrane permeability and thereby the apoptotic program. The anti-apoptotic protein Bcl-2 binds to the pro-apoptotic protein Bax to prevent Bax homo-oligomerization required for membrane permeabilization. Here, we...

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Detalhes bibliográficos
Main Authors: Ding, Jingzhen, Zhang, Zhi, Roberts, G. Jane, Falcone, Mina, Miao, Yiwei, Shao, Yuanlong, Zhang, Xuejun C., Andrews, David W., Lin, Jialing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937903/
https://ncbi.nlm.nih.gov/pubmed/20584903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148361
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