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BH3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes
Pro‐apoptotic Bax induces mitochondrial outer membrane permeabilization (MOMP) by forming oligomers through a largely undefined process. Using site‐specific disulfide crosslinking, compartment‐specific chemical labeling, and mutational analysis, we found that activated integral membrane Bax proteins...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4718459/ https://ncbi.nlm.nih.gov/pubmed/26702098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591552 |
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