BH3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

Pro‐apoptotic Bax induces mitochondrial outer membrane permeabilization (MOMP) by forming oligomers through a largely undefined process. Using site‐specific disulfide crosslinking, compartment‐specific chemical labeling, and mutational analysis, we found that activated integral membrane Bax proteins...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Zhang, Zhi, Subramaniam, Sabareesh, Kale, Justin, Liao, Chenyi, Huang, Bo, Brahmbhatt, Hetal, Condon, Samson GF, Lapolla, Suzanne M, Hays, Franklin A, Ding, Jingzhen, He, Feng, Zhang, Xuejun C, Li, Jianing, Senes, Alessandro, Andrews, David W, Lin, Jialing
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718459/
https://ncbi.nlm.nih.gov/pubmed/26702098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591552
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