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Bax dimerizes via a symmetric BH3:groove interface during apoptosis
During apoptotic cell death, Bax and Bak change conformation and homo-oligomerize to permeabilize mitochondria. We recently reported that Bak homodimerizes via an interaction between the BH3 domain and hydrophobic surface groove, that this BH3:groove interaction is symmetric, and that symmetric dime...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307980/ https://ncbi.nlm.nih.gov/pubmed/22015607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.138 |
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