Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization

The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3,969-amino-acid nuclear protein homologous to Drosophila trithorax and is required to maintain proper Hox gene expression. Chromosome translocations in human leukemia disrupt MLL (11q23), generating chimeric proteins between the N terminus...

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Detalhes bibliográficos
Main Authors: Hsieh, James J.-D., Ernst, Patricia, Erdjument-Bromage, Hediye, Tempst, Paul, Korsmeyer, Stanley J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140678/
https://ncbi.nlm.nih.gov/pubmed/12482972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.186-194.2003
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