Proteolytic Cleavage of MLL Generates a Complex of N- and C-Terminal Fragments That Confers Protein Stability and Subnuclear Localization

The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3,969-amino-acid nuclear protein homologous to Drosophila trithorax and is required to maintain proper Hox gene expression. Chromosome translocations in human leukemia disrupt MLL (11q23), generating chimeric proteins between the N terminus...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Hsieh, James J.-D., Ernst, Patricia, Erdjument-Bromage, Hediye, Tempst, Paul, Korsmeyer, Stanley J.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2003
Matèries:	Gene Expression
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140678/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12482972/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.1.186-194.2003
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