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Taspase1 Functions as a Non-oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
Taspase1 (TASP-1), the MLL and TFIIAα-β cleaving protease, enables cell proliferation and permits oncogenic initiation. Here, we demonstrate its critical role in cancer maintenance and thus offer a new anticancer target. Taspase1 is over-expressed in primary human cancers and deficiency of Taspase1...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909739/ https://ncbi.nlm.nih.gov/pubmed/20516119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0027 |
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