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Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription

Head morphogenesis requires complex signal relays to enable precisely coordinated proliferation, migration, and patterning. Here, we demonstrate that, during mouse head formation, taspase1-mediated (TASP1-mediated) cleavage of the general transcription factor TFIIA ensures proper coordination of rap...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Takeda, Shugaku, Sasagawa, Satoru, Oyama, Toshinao, Searleman, Adam C., Westergard, Todd D., Cheng, Emily H., Hsieh, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362222/
https://ncbi.nlm.nih.gov/pubmed/25664857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77075
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