Taspase1 Functions as a Non-oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

Taspase1 (TASP-1), the MLL and TFIIAα-β cleaving protease, enables cell proliferation and permits oncogenic initiation. Here, we demonstrate its critical role in cancer maintenance and thus offer a new anticancer target. Taspase1 is over-expressed in primary human cancers and deficiency of Taspase1...

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Bibliographic Details
Main Authors: Chen, David Y., Liu, Han, Takeda, Shugaku, Tu, Ho-Chou, Sasagawa, Satoru, Van Tine, Brian A., Lu, Dongsi, Cheng, Emily H.-Y., Hsieh, James J.-D.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909739/
https://ncbi.nlm.nih.gov/pubmed/20516119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0027
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