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Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer
Inactivation of the von Hippel-Lindau tumor suppressor (VHL) is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC), leading to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. He...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3540187/ https://ncbi.nlm.nih.gov/pubmed/23223005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3029 |
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