Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer

Inactivation of the von Hippel-Lindau tumor suppressor (VHL) is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC), leading to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. He...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Vanharanta, Sakari, Shu, Weiping, Brenet, Fabienne, Hakimi, A. Ari, Heguy, Adriana, Viale, Agnes, Reuter, Victor E., Hsieh, James J.-D., Scandura, Joseph M., Massagué, Joan
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540187/
https://ncbi.nlm.nih.gov/pubmed/23223005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3029
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker