Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer

Inactivation of the von Hippel-Lindau tumor suppressor (VHL) is an archetypical tumor-initiating event in clear cell renal carcinoma (ccRCC), leading to the activation of hypoxia-inducible transcription factors (HIFs). However, VHL mutation status in ccRCC is not correlated with clinical outcome. He...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Vanharanta, Sakari, Shu, Weiping, Brenet, Fabienne, Hakimi, A. Ari, Heguy, Adriana, Viale, Agnes, Reuter, Victor E., Hsieh, James J.-D., Scandura, Joseph M., Massagué, Joan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540187/
https://ncbi.nlm.nih.gov/pubmed/23223005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3029
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky