Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency

Juvenile myelomonocytic leukemia is a rare myeloproliferative neoplasm characterized by hyperactive RAS signaling. Neurofibromin1 (encoded by the NF1 gene) is a negative regulator of RAS activation. Patients with neurofibromatosis type 1 harbor loss-of-function mutations in NF1 and have a 200- to 50...

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Publicado no:Haematologica
Main Authors: Sachs, Zohar, Been, Raha A., DeCoursin, Krista J., Nguyen, Hanh T., Mohd Hassan, Nurul A., Noble-Orcutt, Klara E., Eckfeldt, Craig E., Pomeroy, Emily J., Diaz-Flores, Ernesto, Geurts, Jennifer L., Diers, Miechaleen D., Hasz, Diane E., Morgan, Kelly J., MacMillan, Margaret L., Shannon, Kevin M., Largaespada, David A., Wiesner, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5046648/
https://ncbi.nlm.nih.gov/pubmed/27418650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.136002
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