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β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
Neurofibromatosis type 1 (NF1) syndrome is caused by germline mutations in the NF1 tumor suppressor, which encodes neurofibromin, a GTPase activating protein for Ras. Children with NF1 are predisposed to juvenile myelomonocytic leukemia (JMML) and lethally irradiated mice given transplants with homo...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1794059/ https://ncbi.nlm.nih.gov/pubmed/17090653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-025395 |
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