β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

Neurofibromatosis type 1 (NF1) syndrome is caused by germline mutations in the NF1 tumor suppressor, which encodes neurofibromin, a GTPase activating protein for Ras. Children with NF1 are predisposed to juvenile myelomonocytic leukemia (JMML) and lethally irradiated mice given transplants with homo...

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Detalhes bibliográficos
Main Authors: Kim, Andrew, Morgan, Kelly, Hasz, Diane E., Wiesner, Stephen M., Lauchle, Jennifer O., Geurts, Jennifer L., Diers, Miechaleen D., Le, Doan T., Kogan, Scott C., Parada, Luis F., Shannon, Kevin, Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794059/
https://ncbi.nlm.nih.gov/pubmed/17090653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-025395
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