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Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice
Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to conventional chemotherapy. Conditional inactivation of the Nf1 tumor suppressor in hematopoietic cells of mice causes a progr...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533281/ https://ncbi.nlm.nih.gov/pubmed/23221337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63193 |
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