Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to conventional chemotherapy. Conditional inactivation of the Nf1 tumor suppressor in hematopoietic cells of mice causes a progr...

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Detalhes bibliográficos
Main Authors: Chang, Tiffany, Krisman, Kimberly, Theobald, Emily Harding, Xu, Jin, Akutagawa, Jon, Lauchle, Jennifer O., Kogan, Scott, Braun, Benjamin S., Shannon, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533281/
https://ncbi.nlm.nih.gov/pubmed/23221337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63193
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