Preclinical efficacy of MEK inhibition in Nras-mutant AML

Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with antecedent molecular lesions in leukemogenesis, but have limited independent prognostic significance. Using short hairpin RNA–mediated knockdown...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Burgess, Michael R., Hwang, Eugene, Firestone, Ari J., Huang, Tannie, Xu, Jin, Zuber, Johannes, Bohin, Natacha, Wen, Tiffany, Kogan, Scott C., Haigis, Kevin M., Sampath, Deepak, Lowe, Scott, Shannon, Kevin, Li, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271180/
https://ncbi.nlm.nih.gov/pubmed/25361812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-574582
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