BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells

Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow (BM) blast infiltration. Using a transgenic mouse model, MRP8[NRASD12/hBCL-2], in which the NRAS:BCL-2 complex at the mitochondria induces MDS progressing to AML with dysplastic f...

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Autors principals: Beurlet, Stephanie, Omidvar, Nader, Gorombei, Petra, Krief, Patricia, Le Pogam, Carole, Setterblad, Niclas, de la Grange, Pierre, Leboeuf, Christophe, Janin, Anne, Noguera, Maria-Elena, Hervatin, Florence, Sarda-Mantel, Laure, Konopleva, Marina, Andreeff, Michael, Tu, Andrea W., Fan, Alice C., Felsher, Dean W., Whetton, Anthony, Pla, Marika, West, Robert, Fenaux, Pierre, Chomienne, Christine, Padua, Rose Ann
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799000/
https://ncbi.nlm.nih.gov/pubmed/23943652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445635
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