BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia

Cancer cells acquire disruptions in normal signal transduction pathways and homeostatic mechanisms that would trigger apoptosis in normal cells. These abnormalities include genomic instability, oncogene activation, and growth factor independent proliferation. Therefore, cancer cells likely require a...

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Hlavní autoři: Del Gaizo Moore, Victoria, Schlis, Krysta D., Sallan, Stephen E., Armstrong, Scott A., Letai, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234061/
https://ncbi.nlm.nih.gov/pubmed/18056841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098012
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