BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia

Cancer cells acquire disruptions in normal signal transduction pathways and homeostatic mechanisms that would trigger apoptosis in normal cells. These abnormalities include genomic instability, oncogene activation, and growth factor independent proliferation. Therefore, cancer cells likely require a...

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Bibliografiske detaljer
Main Authors: Del Gaizo Moore, Victoria, Schlis, Krysta D., Sallan, Stephen E., Armstrong, Scott A., Letai, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234061/
https://ncbi.nlm.nih.gov/pubmed/18056841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098012
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