Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Acute Lymphoblastic Leukemia (ALL) is a hematopoietic malignancy derived from immature B-and T-lymphoid cells (T-ALL). In T-ALL there is an early T-cell progenitor (ETP) subgroup that has a very high risk for relapse. In this study, we utilized mitochondrial BH3 profiling to determine anti-apoptotic...

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Detalhes bibliográficos
Main Authors: Chonghaile, Triona Ni, Roderick, Justine E., Glenfield, Cian, Ryan, Jeremy, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Wood, Brent, DeAngelo, Daniel J., Stone, Richard, Harris, Marian, Gutierrez, Alejandro, Kelliher, Michelle A., Letai, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154982/
https://ncbi.nlm.nih.gov/pubmed/24994123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0353
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