Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Acute Lymphoblastic Leukemia (ALL) is a hematopoietic malignancy derived from immature B-and T-lymphoid cells (T-ALL). In T-ALL there is an early T-cell progenitor (ETP) subgroup that has a very high risk for relapse. In this study, we utilized mitochondrial BH3 profiling to determine anti-apoptotic...

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Hlavní autoři: Chonghaile, Triona Ni, Roderick, Justine E., Glenfield, Cian, Ryan, Jeremy, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Wood, Brent, DeAngelo, Daniel J., Stone, Richard, Harris, Marian, Gutierrez, Alejandro, Kelliher, Michelle A., Letai, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154982/
https://ncbi.nlm.nih.gov/pubmed/24994123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0353
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