Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Acute Lymphoblastic Leukemia (ALL) is a hematopoietic malignancy derived from immature B-and T-lymphoid cells (T-ALL). In T-ALL there is an early T-cell progenitor (ETP) subgroup that has a very high risk for relapse. In this study, we utilized mitochondrial BH3 profiling to determine anti-apoptotic...

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Hoofdauteurs: Chonghaile, Triona Ni, Roderick, Justine E., Glenfield, Cian, Ryan, Jeremy, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Wood, Brent, DeAngelo, Daniel J., Stone, Richard, Harris, Marian, Gutierrez, Alejandro, Kelliher, Michelle A., Letai, Anthony
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154982/
https://ncbi.nlm.nih.gov/pubmed/24994123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0353
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