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Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy

Hypoxia, a characteristic of most human solid tumors, is a major obstacle to successful radiotherapy. While moderate acute hypoxia increases cell survival, chronic cycling hypoxia triggers adaptation processes, leading to the clonal selection of hypoxia-tolerant, apoptosis-resistant cancer cells. Ou...

詳細記述

保存先:
書誌詳細
出版年:Cell Death Dis
主要な著者: Ritter, Violetta, Krautter, Franziska, Klein, Diana, Jendrossek, Verena, Rudner, Justine
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8277842/
https://ncbi.nlm.nih.gov/pubmed/34257274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03971-7
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