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ABT-199: A New Hope for Selective BCL-2 Inhibition

ABT-199 is a new selective small molecule inhibitor of BCL-2 that appears to spare platelets while achieving potent antitumor activity. Assays that can predict the efficacy of ABT-199 in individual tumors will be critical in determining how best to incorporate this promising agent into the armamenta...

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Detalles Bibliográficos
Autores principales: Davids, Matthew S., Letai, Anthony
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693952/
https://ncbi.nlm.nih.gov/pubmed/23410971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.01.018
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