Selective BCL-2 Inhibition by ABT-199 Causes On Target Cell Death in Acute Myeloid Leukemia

B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that are best treated by inhibition of BCL-2. Here we demonstrate that acute myeloid leukemia (AML) cell lines, primary patient samples, and murine pr...

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Hauptverfasser: Pan, Rongqing, Hogdal, Leah J., Benito, Juliana M, Bucci, Donna, Han, Lina, Borthakur, Gautam, Cortes, Jorge, DeAngelo, Daniel J., Debose, LaKeisha, Mu, Hong, Döhner, Hartmut, Gaidzik, Verena I., Galinsky, Ilene, Golfman, Leonard S., Haferlach, Torsten, Harutyunyan, Karine G., Hu, Jianhua, Leverson, Joel D, Marcucci, Guido, Müschen, Markus, Newman, Rachel, Park, Eugene, Ruvolo, Peter P., Ruvolo, Vivian, Ryan, Jeremy, Schindela, Sonja, Zweidler-McKay, Patrick, Stone, Richard M., Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina, Letai, Anthony G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975047/
https://ncbi.nlm.nih.gov/pubmed/24346116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0609
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