Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial el...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Velez, Juliana, Pan, Rongqing, Lee, Jason T.C., Enciso, Leonardo, Suarez, Marta, Duque, Jorge Eduardo, Jaramillo, Daniel, Lopez, Catalina, Morales, Ludis, Bornmann, William, Konopleva, Marina, Krystal, Gerald, Andreeff, Michael, Samudio, Ismael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239486/
https://ncbi.nlm.nih.gov/pubmed/27283492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9843
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