Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial el...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Velez, Juliana, Pan, Rongqing, Lee, Jason T.C., Enciso, Leonardo, Suarez, Marta, Duque, Jorge Eduardo, Jaramillo, Daniel, Lopez, Catalina, Morales, Ludis, Bornmann, William, Konopleva, Marina, Krystal, Gerald, Andreeff, Michael, Samudio, Ismael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239486/
https://ncbi.nlm.nih.gov/pubmed/27283492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9843
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