Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial el...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Velez, Juliana, Pan, Rongqing, Lee, Jason T.C., Enciso, Leonardo, Suarez, Marta, Duque, Jorge Eduardo, Jaramillo, Daniel, Lopez, Catalina, Morales, Ludis, Bornmann, William, Konopleva, Marina, Krystal, Gerald, Andreeff, Michael, Samudio, Ismael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239486/
https://ncbi.nlm.nih.gov/pubmed/27283492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9843
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