Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that Metformin and rotenone inhibit mitochondrial el...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Velez, Juliana, Pan, Rongqing, Lee, Jason T.C., Enciso, Leonardo, Suarez, Marta, Duque, Jorge Eduardo, Jaramillo, Daniel, Lopez, Catalina, Morales, Ludis, Bornmann, William, Konopleva, Marina, Krystal, Gerald, Andreeff, Michael, Samudio, Ismael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239486/
https://ncbi.nlm.nih.gov/pubmed/27283492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9843
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