Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemi...

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Foilsithe in:Cancer Cell
Main Authors: Pan, Rongqing, Ruvolo, Vivian, Mu, Hong, Leverson, Joel D., Nichols, Gwen, Reed, John C., Konopleva, Marina, Andreeff, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730338/
https://ncbi.nlm.nih.gov/pubmed/29232553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.003
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