Wird geladen...

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Cell
Hauptverfasser: Pan, Rongqing, Ruvolo, Vivian, Mu, Hong, Leverson, Joel D., Nichols, Gwen, Reed, John C., Konopleva, Marina, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730338/
https://ncbi.nlm.nih.gov/pubmed/29232553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.11.003
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!