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A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice
Chronic and juvenile myelomonocytic leukemias (CMML and JMML) are aggressive myeloproliferative neoplasms that are incurable with conventional chemotherapy. Mutations that deregulate Ras signaling play a central pathogenic role in both disorders, and Mx1-Cre, Kras(LSL-G12D) mice that express the Kra...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3265440/ https://ncbi.nlm.nih.gov/pubmed/21451123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001069 |
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