Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

Overactive RAS signaling is prevalent in juvenile myelomonocytic leukemia (JMML) and the myeloproliferative variant of chronic myelomonocytic leukemia (MP-CMML) in humans, and both are refractory to conventional chemotherapy. Conditional activation of a constitutively active oncogenic Nras (Nras(G12...

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Autores principales: Kong, Guangyao, Wunderlich, Mark, Yang, David, Ranheim, Erik A., Young, Ken H., Wang, Jinyong, Chang, Yuan-I, Du, Juan, Liu, Yangang, Tey, Sin Ruow, Zhang, Xinmin, Juckett, Mark, Mattison, Ryan, Damnernsawad, Alisa, Zhang, Jingfang, Mulloy, James C., Zhang, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038579/
https://ncbi.nlm.nih.gov/pubmed/24812670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74182
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