Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm

Overactive RAS signaling is prevalent in juvenile myelomonocytic leukemia (JMML) and the myeloproliferative variant of chronic myelomonocytic leukemia (MP-CMML) in humans, and both are refractory to conventional chemotherapy. Conditional activation of a constitutively active oncogenic Nras (Nras(G12...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kong, Guangyao, Wunderlich, Mark, Yang, David, Ranheim, Erik A., Young, Ken H., Wang, Jinyong, Chang, Yuan-I, Du, Juan, Liu, Yangang, Tey, Sin Ruow, Zhang, Xinmin, Juckett, Mark, Mattison, Ryan, Damnernsawad, Alisa, Zhang, Jingfang, Mulloy, James C., Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038579/
https://ncbi.nlm.nih.gov/pubmed/24812670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74182
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados