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Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions
Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (Nras(G12D/+)) in hematopoietic cells leads to expansion of myeloid progenitors, increased long-term reconstitution of bone marrow cells, and a chronic myeloproliferative n...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3695364/ https://ncbi.nlm.nih.gov/pubmed/23687087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-475863 |
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