Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions

Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (Nras(G12D/+)) in hematopoietic cells leads to expansion of myeloid progenitors, increased long-term reconstitution of bone marrow cells, and a chronic myeloproliferative n...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Jinyong, Kong, Guangyao, Liu, Yangang, Du, Juan, Chang, Yuan-I, Tey, Sin Ruow, Zhang, Xinmin, Ranheim, Erik A., Saba-El-Leil, Marc K., Meloche, Sylvain, Damnernsawad, Alisa, Zhang, Jingfang, Zhang, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695364/
https://ncbi.nlm.nih.gov/pubmed/23687087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-475863
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