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Palmitoylation of oncogenic NRAS is essential for leukemogenesis

Activating mutations of NRAS are common in acute myeloid leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. Like all RAS proteins, NRAS must undergo a series of post-translational modifications for differential targeting to distinct membrane subdomains. Although farnesylation i...

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Detalhes bibliográficos
Main Authors: Cuiffo, Benjamin, Ren, Ruibao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867268/
https://ncbi.nlm.nih.gov/pubmed/20200357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213876
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