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Palmitoylation of oncogenic NRAS is essential for leukemogenesis
Activating mutations of NRAS are common in acute myeloid leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. Like all RAS proteins, NRAS must undergo a series of post-translational modifications for differential targeting to distinct membrane subdomains. Although farnesylation i...
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Asıl Yazarlar: | , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
American Society of Hematology
2010
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867268/ https://ncbi.nlm.nih.gov/pubmed/20200357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213876 |
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