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Palmitoylation of oncogenic NRAS is essential for leukemogenesis

Activating mutations of NRAS are common in acute myeloid leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. Like all RAS proteins, NRAS must undergo a series of post-translational modifications for differential targeting to distinct membrane subdomains. Although farnesylation i...

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Detaylı Bibliyografya
Asıl Yazarlar: Cuiffo, Benjamin, Ren, Ruibao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867268/
https://ncbi.nlm.nih.gov/pubmed/20200357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-213876
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