Unique dependence on Sos1 in Kras(G12D)-induced leukemogenesis

We and others have previously shown that Kras(G12D) is a much more potent oncogene than oncogenic Nras in hematological malignancies. We attributed the strong leukemogenic activity of Kras(G12D) at least partially to its unique capability to hyperactivate wild-type (WT) Nras and Hras. Here, we repor...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: You, Xiaona, Kong, Guangyao, Ranheim, Erik A., Yang, David, Zhou, Yun, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293870/
https://ncbi.nlm.nih.gov/pubmed/30377195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-09-874107
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