Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis

Despite the well-established role of oncogenic RAS in promoting tumor formation, whether and how wild-type (WT) Ras inhibits tumorigenesis under physiological conditions remains controversial. Here, we show that in a fraction of endogenous oncogenic Kras-induced hematopoietic malignancies, including...

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Bibliographic Details
Published in:Leukemia
Main Authors: Kong, Guangyao, Chang, Yuan-I, Damnernsawad, Alisa, You, Xiaona, Du, Juan, Ranheim, Erik A., Lee, Woojong, Ryu, Myung-Jeom, Zhou, Yun, Xing, Yongna, Chang, Qiang, Burd, Christin E., Zhang, Jing
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316475/
https://ncbi.nlm.nih.gov/pubmed/27055865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.40
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