Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis

Oncogenic NRAS and KRAS mutations are prevalent in human juvenile and chronic myelomonocytic leukemia (JMML/CMML). However, additional genetic mutations cooperating with oncogenic RAS in JMML/CMML progression and/or their transformation to acute myeloid leukemia (AML) remain largely unknown. Here, w...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Chang, Yuan-I, You, Xiaona, Kong, Guangyao, Ranheim, Erik A., Wang, Jinyong, Du, Juan, Liu, Yangang, Zhou, Yun, Ryu, Myung-Jeom, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558337/
https://ncbi.nlm.nih.gov/pubmed/25801914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.85
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