Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis

We previously showed that widespread expression of Nras G12D/G12D from its endogenous locus in mice leads to an acute myeloproliferative disease (MPD) with a complete penetrance, whereas bone marrow-specific expression of Nras G12D/G12D in recipient mice did not result in sustained MPD phenotypes bu...

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Hauptverfasser: Wang, Jinyong, Liu, Yangang, Tan, Li Xuan, Lo, Juinn Cherng, Du, Juan, Ryu, Myung-Jeom, Ranheim, Erik A, Zhang, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218596/
https://ncbi.nlm.nih.gov/pubmed/21857161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.17.17195
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