Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

Both monoallelic and biallelic oncogenic NRAS mutations are identified in human leukemias, suggesting a dose-dependent role of oncogenic NRAS in leukemogenesis. Here, we use a hypomorphic oncogenic Nras allele and a normal oncogenic Nras allele (Nras G12D(hypo) and Nras G12D, respectively) to create...

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Autores principales: Wang, Jinyong, Liu, Yangang, Li, Zeyang, Wang, Zhongde, Tan, Li Xuan, Ryu, Myung-Jeom, Meline, Benjamin, Du, Juan, Young, Ken H., Ranheim, Erik, Chang, Qiang, Zhang, Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138689/
https://ncbi.nlm.nih.gov/pubmed/21586752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-326058
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