p53(−/−) synergizes with enhanced Nras(G12D) signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia

Somatic mutations in TP53 and NRAS are associated with transformation of human chronic myeloid diseases to acute myeloid leukemia (AML). Here, we report that concurrent RAS pathway and TP53 mutations are identified in a subset of AML patients and confer an inferior overall survival. To further inves...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhang, Jingfang, Kong, Guangyao, Rajagopalan, Adhithi, Lu, Li, Song, Jingming, Hussaini, Mohamed, Zhang, Xinmin, Ranheim, Erik A., Liu, Yangang, Wang, Jinyong, Gao, Xin, Chang, Yuan-I, Johnson, Kirby D., Zhou, Yun, Yang, David, Bhatnagar, Bhavana, Lucas, David M., Bresnick, Emery H., Zhong, Xuehua, Padron, Eric, Zhang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248933/
https://ncbi.nlm.nih.gov/pubmed/27815262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-719237
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