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Key roles of EMT for adaptive resistance to MEK inhibitor in KRAS mutant lung cancer
KRAS is frequently mutated in a variety of cancers including lung cancer. Whereas the mitogen-activated protein kinase (MAPK) is a well-known effector pathway of KRAS, blocking this pathway with MEK inhibitors is relatively ineffective. One major contributor to limited efficacy is attributed to the...
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| Publicado no: | Small GTPases |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5584737/ https://ncbi.nlm.nih.gov/pubmed/27392325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1210369 |
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