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The GAP Related Domain of Neurofibromin Attenuates Proliferation and Downregulates N- and K-Ras Activation in Nf1-Negative AML Cells
Inactivation of the NF1 tumor suppressor causes myeloproliferative diseases. NF1 encodes a GTPase activating protein (GAP) for Ras. Myeloid cells with loss of NF1 have high levels of Ras-GTP, functionally equivalent to the effects of RAS oncogenes. We investigated the effects of the NF1 GAP-related...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788398/ https://ncbi.nlm.nih.gov/pubmed/17222906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2006.11.022 |
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