The GAP Related Domain of Neurofibromin Attenuates Proliferation and Downregulates N- and K-Ras Activation in Nf1-Negative AML Cells

Inactivation of the NF1 tumor suppressor causes myeloproliferative diseases. NF1 encodes a GTPase activating protein (GAP) for Ras. Myeloid cells with loss of NF1 have high levels of Ras-GTP, functionally equivalent to the effects of RAS oncogenes. We investigated the effects of the NF1 GAP-related...

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Hauptverfasser: Morgan, Kelly J., Rowley, Matthew A., Wiesner, Stephen M., Hasz, Diane E., Van Ness, Brian, Largaespada, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788398/
https://ncbi.nlm.nih.gov/pubmed/17222906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2006.11.022
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