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Downregulation of Rap1GAP Contributes to Ras Transformation

Although abundant in well-differentiated rat thyroid cells, Rap1GAP expression was extinguished in a subset of human thyroid tumor-derived cell lines. Intriguingly, Rap1GAP was downregulated selectively in tumor cell lines that had acquired a mesenchymal morphology. Restoring Rap1GAP expression to t...

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Detalhes bibliográficos
Main Authors: Tsygankova, Oxana M., Prendergast, Gregory V., Puttaswamy, Kanchan, Wang, Yan, Feldman, Michael D., Wang, Hongbin, Brose, Marcia S., Meinkoth, Judy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099240/
https://ncbi.nlm.nih.gov/pubmed/17646383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00155-07
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