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Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion

The significance of the widespread downregulation of Rap1GAP in human tumors is unknown. In previous studies we demonstrated that silencing Rap1GAP expression in human colon cancer cells resulted in sustained increases in Rap activity, enhanced spreading on collagen and the weakening of cell-cell co...

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Bibliographic Details
Main Authors: Vuchak, Lisa A, Tsygankova, Oxana M, Meinkoth, Judy L
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210300/
https://ncbi.nlm.nih.gov/pubmed/21785277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cam.5.4.17041
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