NRAS(G12V) oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific functions of these pathways in AML are unclear, thwarting the rational application of targeted therapeutics. To elucidate the downstr...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239336/
https://ncbi.nlm.nih.gov/pubmed/25316678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-521708
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